Depends on what's in your hand, really. This game only has 6-7 turns for each side max, so if you really want to waste one turn bluffing your opponent, that's up to you I guess. Personally I'd rather play what I can in the early sites so I can start cycling my deck and drawing new stuff.
Besides, the turn(S) before the first sanctuary aren't really about doing damage; they're about setting up your respective sides for the more dangerous areas of the site path later on in the game. If you do more wounds than can be healed at site 3, then great. If not, that's fine too. One trap some players tend to fall into in this game is to hold onto cards for too long, clogging their hand. In 95% of your games, the best option is for you to play every possible card you have in your hand during each turn.