The era of the CCG is basically over, and has been for a while.
When was the last highly successful CCG launch? I would say World of Warcraft in 2006. Looking at the Gencon list, what's there beyond Magic for adults? L5R? Star Trek? I see The Spoils and Universal Fighting System, both from 2006. I wouldn't consider those massive successes.
The problem is that the CCG model is too expensive. In the traditional model, a playset involves about 200 rares per year, times 4 copies. That's roughly 20 booster boxes - $1500 to $2000 per year. Even getting cards as a Rider, I spent $1000-1200 on cards each year. LotR was pretty good in that you could build playable decks without tons of rares - I built and won with less than 10, sometimes. But it would be hard to play for under $500 a year.
I could buy an Xbox 360 and 5 games for that $500. An MMORPG costs what, $20 a month? Plus, the Xbox and computer are there all the time, where it's easy to find other players and you don't have to travel. Still, many MMORPGs wind down and are closed.
To get enough players for a new TCG, you need to have high popularity - more than Battlestar Galactica or .hack. Yugioh and Pokemon hit their young target audiences. LotR and WoW had huge fanbases. Even in 2002, I figured LotR would trail off after the movies ended; I would have liked to see a planned Shadows block and wind-down, which would have been much cleaner than the mess we wound up with.
Magic has survived by having the largest audience, but even they had a setback this year with the best card by far, Jace, the Mind Scuptor, costing $80. Their attendance went notably down. Fantasy Flight has survived by switching to a fixed-product model. Looking at the Game of Thrones products, it appears that their monthly chapter packs cost $15, and there are one or two larger sets each year at roughly $30. (Someone jump in if I'm mistaken here.) That's close to MMORPG pricing, which makes it a competitive decision. And they're being vastly helped by the HBO series.
Fight Klub has no inherent fanbase and no outside promotion. The Decipher embezzlement loss drained the reserves, and the "insider gang" model didn't help, but it had roughly zero chance of success from the start.